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Macromolecular Crystallography is at the heart of the genomics age allowing the determination of the three-dimensional structures of the proteins for which the genomes code for. This information is used to determine and understand their function and to develop new drugs that cure diseases. This course teaches students the fundamentals of diffraction theory, crystal properties and the basic concepts of solving the structures of macromolecular crystals. The course is appropriate for advanced undergraduate and graduate students majoring in physics, chemistry, and biology.